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. 2021 Mar 15;12(3):280. doi: 10.1038/s41419-021-03562-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Timeline of PDX treatment experiment in Nlrp3^+/+ and Nlrp3^−/− mouse CIA models. B Clinical scores of PDX-treated CIA models established using Nlrp3^+/+ and Nlrp3^−/− CIA mice. Statistical significance was defined by ANOVA of repeated measurements. C H&E staining of knee joints from PDX-treated Nlrp3^+/+ and Nlrp3^−/− CIA mice (40×, 100×) (upper panel) and histopathological analysis of H&E staining (F[3,40] = 54.02) (lower panel). D Concentrations of serum cytokines IL-1β, IL-18, IL-17A, IL-10, and TGF-β in PDX-treated Nlrp3^+/+ and Nlrp3^−/− CIA mice as shown by ELISA. E Expression of NLRP3 mRNA in lymphocytes from PDX-treated Nlrp3^+/+ and Nlrp3^−/− CIA mice as shown by RT-qPCR (F[6,18] = 18.62). F NLRP3 protein levels in lymph nodes of PDX-treated Nlrp3^+/+ and Nlrp3^−/− CIA mice as shown by WB.