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. 2021 Mar 15;7:48. doi: 10.1038/s41420-021-00439-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The mRNA levels of Col1a1 and Mmp2 in lungs from the indicated groups of mice were detected by qPCR. B Representative images show H&E, Masson’s trichrome, Sirius red, Collagen, and α-SMA staining of lung sections from the indicated groups of mice. Scale bars, 100 μm. C, D Western blotting (C) and subsequent quantification of p-ERK, p-SMAD2/3, α-SMA, and Collagen (D) in whole-lung homogenates of mice from the indicated groups. Actin was used as a loading control. NS indicates a nonsignificant difference. E Two different GSEA data showing the significant suppression of non-canonical ERK signaling gene sets in NP-011-administered group compared to BLM-treated group in PF model. Data are presented as means ± SD; n = 10 (control), n = 11 (BLM), n = 5 (BLM + NP-011 IT), n = 7 (BLM + NP-011 IT). *p < 0.05, **p < 0.01 (ANOVA).