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. 2021 Mar 15;7:48. doi: 10.1038/s41420-021-00439-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A H&E, Masson’s trichrome, and Sirius red staining of representative lung sections from each group of treated mice. The effects of NP-011, PFD and Nib on the expression of collagen and α-SMA in lung tissues of BLM-induced PF in mice. Scale bars, 100 μm. B qPCR analysis for Col1a1 expression. C Quantification of collagen-positive areas as measured by confocal microscopy. D Whole lungs from control or BLM-challenged mice treated with NP-011, PFD, and Nib were used for Western blotting using p-ERK, Collagen, α-SMA, and a loading control (Actin). E Quantification of p-ERK, Collagen, and α-SMA. Data are presented as means ± SD; n = 6 (control), n = 8 (BLM), n = 7 (BLM + NP-011), n = 6 (BLM + PFD), n = 8 (BLM + Nib). *p < 0.05, **p < 0.01 (ANOVA).