Skip to main content
. 2021 Mar 15;11:162. doi: 10.1038/s41398-021-01280-3

Fig. 2. Ngf-knockout mice show increased anxiety and impaired spatial learning.

Fig. 2

A Ngf cKO mice spent less time in the center zone of the open field, but there was no difference in the distance traveled (n = 20–22). B In the elevated plus maze, Ngf cKO mice spent less time in the open arm but there was no difference in the distance traveled. C In the water maze, Ngf cKO mice exhibited impaired learning in the training section. One week later, Ngf cKO mice spent less time in the target zone (n = 8–10). D High-frequency stimulation-induced synaptic plasticity was recorded in the hippocampal CA1 region in WT and Ngf cKO mice (n = 6). The horizontal gray line indicates the average value of the normalized amplitude during the baseline period. E fEPSP slope of STP was dramatically reduced in the Ngf cKO group. F The paired-pulse ratios were similar between Ngf cKO and WT mice; however, Ngf cKO exhibited a trend of enhanced PPR at the use of a 50 ms interstimulus interval.