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. 2021 Mar 2;11:619242. doi: 10.3389/fonc.2021.619242

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Copyright © 2021 Liu, Wang, Liu, Lu, Jiao, Sun and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) From left to right: mRNA expression; mutation frequency; amplification frequency; deletion frequency, and expression versus methylation (gene expression correlation with DNA methylation β value) for MHC molecules, co-stimulators and co-inhibitors in the two subtypes. (B–E) Comparison of the two subtypes in four immunogenicity associated indicators such as TMB (B), SNV neoantigens (C), indel neoantigens (D), and MSI score (E). (F–I) Comparison of the two subtypes in focal (F, G) and broad (H, I) CNV burden. (J, K) The distribution of TCR (J) and BCR (K) diversity in the two subtypes.