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. 2021 Mar 15;12(3):279. doi: 10.1038/s41419-021-03541-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Autophagy of neurons was increased significantly in OGD, and reduced significantly in ORF-CISD1. B The relative expression of LC 3II was obviously increased in OGD, but reduced significantly in ORF-CISD1. OGD oxygen glucose deprivation. C–H The relative expression of ATG12, Beclin-1, P62, and LC 3II was obviously increased, and the relative expression of LC 3I was decreased significantly. However, the expression result of ATG12, Beclin-1, P62, LC 3I, and LC 3II was opposite in the miR127 KO rat group. Scale bar = 20 μm. Data are shown as mean ± s.d. **P < 0.01 with one-way ANOVA or Kruskal–Wallis, n = 6. OGD oxygen glucose deprivation, NC negative control, CISD1 CDGSH iron sulfurdomain-containing protein 1, ORF-CISD1 CISD1 overexpression, CISD1-NC negative control CISD1.