Table 3. Evaluation parameters of in-situ gelling formulations .

Formulation code	Gelation temperature before dilution ( o C )*	Gelation temperature after dilution ( o C )*	Gelling ability#	pH	Spreadability (cm)*	Viscosity (cp at 20 rpm)	Drug release after 8 h ( %)*
F1	20.2±0.1	21.3±0.1	++	4.2	1.0±0.2	2021	46.07±0.5
F2	29.0±0.2	30.1±0.2	+++	4.5	2.5±0.1	2116	46.18±0.3
F3	24.6±0.2	25.4±0.2	+++	6.2	1.3±0.1	1416	38.57±0.2
F4	19.1±0.1	20.7±0.3	++	7.0	1.8±0.1	1596	46.53±0.5
F5	30.4±0.1	31.5±0.2	+++	4.5	3.8±0.2	1095	21.95±1.0
F6	31.1±0.1	32.7±0.1	+++	6.8	2.9±0.3	2020	34.99±0.2
F7	27.9±0.2	28.4±0.2	+++	5.9	2.0±0.2	2165	42.91±0.1
F8	31.7±0.1	32.4±0.2	+++	6.2	3.2±0.1	1995	38.14±0.2
F9	28.2±0.2	29.6±0.2	+++	4.5	2.6±0.2	1982	45.37±0.5
F10	20.6±0.2	21.8±0.2	+++	7.0	1.6±0.2	2591	43.85±0.2
F11	32.3±0.2	33.8±0.2	++	6.0	4.5±0.1	2065	30.72±0.3
F12	33.3±0.2	34.8±0.2	+++	5.2	4.8±0.2	1985	27.99±0.1
F13	26.7±0.2	27.2±0.2	+++	6.5	2.2±0.2	5623	38.57±0.5
F14	34.5±0.2	35.8 ±0.2	+++	5.6	5.3±0.05	2135	28.18±0.2
F15	32.0±0.2	33.2±0.2	+++	6.3	5.5±0.1	4659	42.46±0.3
F16	29.0±0.2	30.2±0.2	+++	5.3	3.3±0.2	3592	46.18±0.5
F17	28.2±0.2	29.7±0.2	+++	5.5	3.5±0.2	3165	45.37±0.1

*Mean ±SD (n=3) #Gelling ability: No phase transition (-), gel formation after 60s and collapsed rapidly within 1 h (+), gel formation after 60s and gel collapsed within 3 h (++) and gel formation within 60s and stable for more than 6 h (+++).