Table 5. Release Kinetics of in-situ gelling formulations .
Code | Zero order | First order | Matrix | Korsmeyer-Peppas | Hixson Crowell | ||
R 2 | R 2 | R 2 | K | R 2 | n | R 2 | |
CBZ NLC dispersion | 0.9814 | 0.9906 | 0.9700 | 18.89 | 0.9920 | 0.6834 | 0.9919 |
CBZ in-situ gel | 0.9797 | 0.9920 | 0.9732 | 12.35 | 0.9936 | 0.6812 | 0.9892 |
CBZ NLC in-situ gel | 0.9835 | 0.9861 | 0.9497 | 14.76 | 0.9540 | 0.6131 | 0.9875 |
Note. CBZ: Carbamazepine, NLC: Nanostructured lipid carriers, K is Higuchi constant and n value in Korsmeyer-Peppas indicates mechanism of drug release