Table 6. Ex vivo diffusion parameters .
Formulations |
Flux (
Jss
± SD)
(mg.cm-2.h-1) |
Permeability coefficient
(
Kp
)
cm.h-1 |
Enhancement
ratio (Er) |
CBZ NLC in-situ gel |
0.0003±0.00001 | 0.0001 | 1.5 |
Plain CBZ in-situ gel |
0.0002±0.0001 | 0.000061 |
Note. Values are expressed as Mean ± SD (n=3), CBZ: Carbamazepine, NLC: Nanostructured lipid carriers Jss: Steady state Flux