Table 2.

Experimental Groups, Group Size, and Administered Treatments

Name of the Group	Group Sizea	Administered Treatment
NC	72	Zebrafish with no xenotransplantation and no SARS-CoV-2 induction
XMC	72	Zebrafish transplanted with human alveolar epithelial A549 cells on the posterior lobe of swim bladder
DC	72	XMC injected with SARS-CoV-2 recombinant S-protein
1X-Dexa-HED	72	DC administered with 0.08 µg/kg body weight of dexamethasone through feed
0.2X-HED	72	DC administered with 6 µg/kg body weight of WiNeWsE through feed
1X-HED	72	DC administered with 28 µg/kg body weight of WiNeWsE through feed
5X-HED	72	DC administered with 142 µg/kg body weight of WiNeWsE through feed

Notes: ^aThere were 24 subjects/group/endpoint. There were three endpoints in this study.

Abbreviations: NC, normal control; XMC, xenotransplant model control; DC, disease control; 1X-Dexa-HED, human equivalent dose of dexamethasone; WiNeWsE, withanone enriched Withania somnifera extract; 0.2X-HED, 0.2X human equivalent dose of WiNeWsE; 1X-HED, human equivalent dose of WiNeWsE; 5X-HED, 5X human equivalent dose of WiNeWsE.