Fig. 1.

Gut colonization by Klebsiella pneumoniae, transit modifications and fecal concentrations of CRO and CTX. (A) Quantification of fecal excretion of ESBL-producing Kp over time according to treatment administered (n = 15 per group). The bars represent the mean and the range. (B) Quantification of fecal excretion of ESBL-producing Kp over time according to treatment administered (n = 15 per group). Lines correspond to loess-smoothed conditional means and shading to SE. (C) Area under the curve (AUC) of ESBL-producing Kp excretion of control, CTX and CRO groups. A statistically significant difference in colonization between CRO and CTX was observed from day 4 to day 12 (p-value = 0.0078, Mann-Whitney test) and is symbolized by an asterisk. (D) CRO fecal concentrations. (E) CTX (squares) and desacetyl-CTX (stars) fecal concentrations. Values were indicated as mean ± SEM (n = 10 per group). Detection threshold was 10 μg/g.