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. 2021 Mar 6;26(5):1424. doi: 10.3390/molecules26051424

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibitory effects of RF on TRPV1-induced neuropeptide expression in UVB-exposed mice skin and UVB- or heat-treated sensory neuronal cells. (A–I) The TRPV1-induced neuropeptide (Cgrp, Pacap, and Vip) expression level was analyzed by qRT-PCR in the skin tissue (A,D,G) (3 mice per group), UVB exposure F11 cell model (B,E,H) and heat exposure F11 cell model (C,F,I) and were normalized to that of Actb and expressed relative to the control group. * p < 0.05 vs. Control; ^$ p < 0.05 vs. UVB or Heat; ^# p < 0.05 vs. RF 50 ms.