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. 2021 Mar 6;26(5):1424. doi: 10.3390/molecules26051424

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Attenuated effects of RF on neuropeptide-induced inflammation in UVB-exposed mice skin and UVB- or heat-treated sensory neuronal cells. (A–I) The neuropeptide-induced inflammation cytokine (Il-1β, Tnf-α, and inos) mRNA expression level was analyzed by qRT-PCR in the skin tissue (A,D,G) (3 mice per group), UVB-CM-treated Raw264.7 cell model (B,E,H) and heat-CM treated Raw264.7 cell model (C,F,I) and were normalized to that of Actb and expressed relative to the control group. * p < 0.05 vs. Control; ^$ p < 0.05 vs. UVB-CM or Heat-CM; ^# p < 0.05 vs. RF 50 ms.