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. 2021 Mar 4;22(5):2547. doi: 10.3390/ijms22052547

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic summarizing findings of let-7/TLR7/TRAIL induced neurodegeneration by ethanol. Left panel: Ethanol causes induction of both let-7b and its receptor TLR7. Middle panel: TLR7 induces expressions of the death receptor ligand TRAIL and its receptors. Right panel: TRAIL induces neuronal death through the induction of caspase cascades. Blocking either let-7b, TLR7, or TRAIL with the let-7 inhibitor, TLR7 siRNA, or a TRAIL neutralizing antibody respectively prevent ethanol-induced neurodegeneration.