Table 1.

Demographics of alcohol use disorder (AUD) and control subjects from New South Wales Brain Tissue Bank.

DSM-5 Alcohol Classification	Age	PMI	RIN Value	Lifetime Alcohol (g)	BAC at Death (g/dL)	Cause of Death and Agonal State/Mode of Death
Control	24	43	6.2	22,000	-	Arrhythmia, Rapid
Control	43	66	7.4	13,000	ND	Pneumonia, Intermediate
Control	44	50	7.1	69,000	-	IHD, Rapid
Control	46	29	4.4	17,300	-	MI, Intermediate
Control	48	24	6.9	59,000	-	IHD, Rapid
Control	50	30	7.5	5500	ND	IHD, Rapid
Control	50	40	8.6	9000	ND	Hemopericardium, Rapid
Control	53	16	7.9	102,000	ND	Cardiomyopathy, Rapid
Control	60	28	8	0	-	IHD, Rapid
Control	62	46	8.8	5000	ND	IHD, Rapid
Mean ± SEM	48 ± 3	33 ± 3	7.28 ± 1	35 ± 13	-	-
AUD, Mild	42	41	6.9	552	0.193	CO and EtOH, Intermediate
AUD, Moderate	43.5	43.5	8	1472	0.174	Bromoxynil/EtOH, Intermediate
AUD, Remission	44	15	7.9	639	ND	IHD, Rapid
AUD, Severe	45	7.5	7.9	1799	0.297	Drowning, Intermediate
AUD, Severe	49	44	6.4	1012	0.03	IHD, Rapid
AUD, Severe	49	16	6.2	613	ND	MI, Rapid
AUD, Moderate	50	17	7.0	2453	ND	IHD, Rapid
AUD, Severe	51	27	7.3	5212	0.395	Acute Bronchitis, Intermediate
AUD, Severe	61	23.5	6.1	8052	ND	Myocarditis, Intermediate
AUD, Severe	61	59	8.3	5621	ND	IHD, Rapid
Mean ± SEM	48 ± 3	31 ± 5	7.2 ± 1	2743 ± 829	-	-

Detailed clinical data were collected for each subject as described in Methods. All subjects were male. AUD—alcohol use disorder, PMI—postmortem interval, RIN—RNA integrity number, BAC—blood alcohol content, ND—not detected, IHD—ischemic heart disease, MI—myocardial infarction, CO—carbon monoxide, EtOH—alcohol. Agonal state terminal phase durations: rapid, <1 h; intermediate, 1–24 h; long term, >24 h.