Table 1.
Summary of preclinical studies on Sonodynamic Therapy for gliomas.
| Sonosensitizer | Title | Authors | Journal; Year |
|---|---|---|---|
| 5-Aminolevulinic Acid | Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat | Ohmura et al. [57] |
Anticancer Res. 2011 Jul;31(7):2527-33. |
| 5-Aminolevulinic Acid | Sono-dynamically induced antitumor effects of 5-aminolevulinic acid and fractionated ultrasound irradiation in an orthotopic rat glioma model | Jeong et al. [58] |
Ultrasound Med Biol. 2012 Dec;38(12):2143-50. |
| 5-Aminolevulinic Acid | Porphyrin derivatives-mediated sonodynamic therapy for malignant gliomas in vitro | Endo et al. [59] |
Ultrasound Med Biol. 2015 Sep;41(9):2458-65. |
| 5-Aminolevulinic Acid | 5-Aminolevulinic acid-mediated sono-sensitization of rat RG2 glioma cells in vitro | Bilmin et al. [60] |
Folia Neuropathol. 2016;54(3):234-240. |
| 5-Aminolevulinic Acid | Hyper-thermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma | Ju et al. [38] |
Tumour Biol. 2016 Aug;37(8):10415-26. |
| 5-Aminolevulinic Acid | Enhancement of antitumor activity by using 5-ALA–mediated sonodynamic therapy (SDT) to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model | Suehiro et al. [36] |
J Neurosurg. 2018 Dec 1;129(6):1416-1428. |
| 5-Aminolevulinic Acid | MR-guided Focused Ultrasound Facilitates sonodynamic therapy with 5-Aminolevulinic Acid in a Rat Glioma Model | Wu et al. [61] |
Sci Rep. 2019 Jul 18;9(1):10465. |
| 5-Aminolevulinic Acid | Sonodynamic therapy for malignant glioma using 220-khz transcranial magnetic resonance imaging-guided focused ultrasound and 5-aminolevulinic acid | Yoshida et al. [62] |
Ultrasound Med Biol. 2019 Feb;45(2):526-538. |
| 5-Aminolevulinic Acid | Low Frequency Ultrasonication Induced Antitumor Effect in 5-Aminolevulinic Acid Treated Malignant Glioma | Yamaguchi et al. [63] |
J Cancer Ther. 2013;04(01):170-175. |
| Fluorescein | Fluorescein-mediated sonodynamic therapy in a rat glioma model | Prada et al. [64] |
J Neurooncol. 2020 Jul;148(3):445-454. |
| Rose Bengal | Sonodynamic Therapy Consisting of Focused Ultrasound and a Photosensitizer Causes a Selective Antitumor Effect in a Rat Intracranial Glioma Model | Nonaka et al. [65] |
Anticancer Res. 2009 Mar;29(3):943-50. |
| Hematoporphyrin Mono-Methil Ether | Study of the mechanism of sonodynamic therapy in a rat glioma model | Song et al. [66] |
Onco Targets Ther. 2014 Sep 30;7:1801-10. |
| Hematoporphyrin Mono-Methil Ether | In vitro study of low intensity ultrasound combined with different doses of photodynamic therapy (PDT): Effects on C6 glioma cells | Li et al. [67] |
Oncol Lett. 2013 Feb;5(2):702-706. |
| Hematoporphyrin Mono-Methil Ether | In vitro study of hematoporphyrin monomethyl ether-mediated sonodynamic effects on C6 glioma cells | Li et al. [68] |
Neurol Sci. 2008 Sep;29(4):229-35. |
| Hematoporphyrin Mono-Methil Ether | In vitro stimulation of calcium overload and apoptosis by sonodynamic therapy combined with hematoporphyrin monomethyl ether in C6 glioma cells | Dai et al. [41] |
Oncol Lett. 2014 Oct;8(4):1675-1681. |
| Hema-toporphyrin Mono-Methil Ether | Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy | Li et al. [69] |
Int J Radiat Biol. 2011 Oct;87(10):1061-6. |
| Hematoporphyrin Mono-Methil Ether | Apoptotic effect of sonodynamic therapy mediated by hematoporphyrin monomethyl ether on C6 glioma cells in vitro | Dai et al. [70] |
Acta Neurochir (Wien). 2009 Dec;151(12):1655-61. |
| Hematoporphyrin Mono-Methil Ether | Calcium Overload and in vitro Apoptosis of the C6 Glioma Cells Mediated by Sonodynamic Therapy (Hematoporphyrin monomethyl ether and ultrasound) | Hao et al. [40] |
Cell Biochem Biophys. 2014 Nov;70(2):1445-52. |
| Sino-porphyrin | Theragnostic nano-sensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas. | Liu et al. [71] |
J Cell Mol Med. 2018 Nov;22(11):5394-5405 |
| Sino-porphyrin | Sonodynamic Therapy on Intracranial Glioblastoma Xenografts Using Sino-porphyrin Sodium Delivered by Ultrasound with Microbubbles. | Pi et al. [72] |
Ann Biomed Eng. 2019 Feb;47(2):549-562. |
| Sino-porphyrin | Tumor targeting DVDMS-nanoliposomes for an enhanced sonodynamic therapy of gliomas. | Sun et al. [73] |
Biomater Sci. 2019 Feb 26;7(3):985-994. |
| Sino-porphyrin | Sino-porphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma. | An et al. [74] |
Oncol Rep. 2020 Oct;44(4):1596-1604. |
| Photofrin | Glioma stem-like cells are less susceptible than glioma cells to sonodynamic therapy with photofrin | Xu et al. [75] |
Technol Cancer Res Treat. 2012;11(6):615-623. |
| Photofrin | The ABCG2 transporter is a key molecular determinant of the efficacy of sonodynamic therapy with photofrin in glioma stem-like cells. Ultrasonics | Xu et al. [76] |
Ultrasonics. 2013;53(1):232-238. |
| Photolon | Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model | Tserkovsky et al. [77] | Exp Oncol. 2012;34(4):332-335. |
| Photolon | Photolon enhancement of ultrasound cytotoxicity | Tserkovsky et al. [78] | Exp Oncol. 2011 Jun;33(2):107-9. |
| Photolon | Imaging-guided focused ultrasound-induced thermal and sonodynamic effects of nano-sonosensitizers for synergistic enhancement of glioblastoma therapy | Wan et al. [79] |
Biomater Sci. 2019 Jun 25;7(7):3007-3015. |