Table 4.
Descriptive statistics and gene annotations for the significant fertility-related DMRs.
| Location | logFC | p-Value | adj.p.Val | Annotation | Distance ToTSS |
EMSEMBL ID | GENE ID | Description | CG |
|---|---|---|---|---|---|---|---|---|---|
| chr1:35377643-35377942 | 1.20 | 1.86 × 10−2 | 9.96 × 10−1 | Intron | 44,178 | ENSSSCG00000024392 | THEMIS | thymocyte selection associated (Source:VGNC Symbol;Acc:VGNC:98369) | 9 |
| chr1:71457907-71458215 | 1.10 | 4.88 × 10−2 | 9.96 × 10−1 | Promoter | −502 | ENSSSCG00000045756 | 8 | ||
| chr1:89431929-89432118 | 1.63 | 1.54 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −167,999 | ENSSSCG00000046698 | 1 | ||
| chr1:122165935-122166122 | 0.93 | 1.34 × 10−2 | 9.96 × 10−1 | Intron | 26,493 | ENSSSCG00000004648 | FAM227B | family with sequence similarity 227 member B (Source:VGNC Symbol;Acc:VGNC:87961) | 8 |
| chr2:15503913-15504126 | 1.42 | 6.22 × 10−3 | 9.40 × 10−1 | Intron | 27,523 | ENSSSCG00000020542 | U6 | U6 spliceosomal RNA (Source:RFAM;Acc:RF00026) | 10 |
| chr2:65812355-65812642 | 1.18 | 2.39 × 10−2 | 9.96 × 10−1 | Intron | 90,547 | ENSSSCG00000013754 | calcium voltage-gated channel subunit alpha1 A (Source:VGNC Symbol;Acc:VGNC:99705) | 6 | |
| chr2:72272984-72273185 | 1.35 | 4.28 × 10−2 | 9.96 × 10−1 | 5’ UTR | −3761 | ENSSSCG00000013556 | adhesion G protein-coupled receptor E1 (Source:VGNC Symbol;Acc:VGNC:85124) | 21 | |
| chr3:38143485-38143693 | 1.11 | 1.99 × 10−2 | 9.96 × 10−1 | Intron | −29,370 | ENSSSCG00000007950 | ADCY9 | adenylate cyclase 9 (Source:VGNC Symbol;Acc:VGNC:85113) | 6 |
| chr3:111685876-111686073 | 1.76 | 1.24 × 10−2 | 9.96 × 10−1 | Promoter | 2167 | ENSSSCG00000026367 | IFT172 | intraflagellar transport 172 (Source:VGNC Symbol;Acc:VGNC:89046) | 2 |
| chr3:128777380-128777600 | −1.13 | 4.46 × 10−2 | 9.96 × 10−1 | Intron | 8370 | ENSSSCG00000008646 | RNF144A | ring finger protein 144A (Source:VGNC Symbol;Acc:VGNC:92358) | 2 |
| chr4:68193523-68193723 | −1.13 | 2.97 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 31,282 | ENSSSCG00000023848 | VXN | vexin (Source:VGNC Symbol;Acc:VGNC:94889) | 4 |
| chr4:85493823-85493995 | −0.98 | 4.74 × 10−2 | 9.96 × 10−1 | Intron | 86,294 | ENSSSCG00000006329 | LMX1A | LIM homeobox transcription factor 1 alpha (Source:VGNC Symbol;Acc:VGNC:89770) | 6 |
| chr6:19702050-19702740 | 1.18 | 4.64 × 10−2 | 9.96 × 10−1 | Intron | −5977 | ENSSSCG00000002812 | KIFC3 | kinesin family member C3 (Source:VGNC Symbol;Acc:VGNC:89479) | 8 |
| chr6:112264267-112264451 | 0.78 | 2.87 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 259,145 | ENSSSCG00000042906 | 8 | ||
| chr7:99786455-99786655 | 1.23 | 4.55 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −57,879 | ENSSSCG00000051045 | 1 | ||
| chr7:104533019-104533586 | 1.10 | 2.47 × 10−2 | 9.96 × 10−1 | Promoter | −284 | ENSSSCG00000049060 | 16 | ||
| chr9:19560588-19560803 | 1.39 | 1.62 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 12,942 | ENSSSCG00000014905 | TMEM126B | transmembrane protein 126B (Source:NCBI gene (formerly Entrezgene);Acc:100626990) | 6 |
| chr9:91128754-91129011 | 1.85 | 1.65 × 10−2 | 9.96 × 10−1 | Intron | 70,639 | ENSSSCG00000015383 | RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Source:VGNC Symbol;Acc:VGNC:92094) | 1 |
| chr10:19289977-19290168 | 1.28 | 2.26 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −16,228 | ENSSSCG00000033907 | 5 | ||
| chr11:1065989-1066196 | 1.29 | 2.33 × 10−2 | 9.96 × 10−1 | 3’ UTR | 28,854 | ENSSSCG00000009276 | XPO4 | exportin 4 (Source:VGNC Symbol;Acc:VGNC:95004) | 1 |
| chr11:1065989-1066196 | 1.29 | 2.33 × 10−2 | 9.96 × 10−1 | 3’ UTR | 28,854 | 1 | |||
| chr11:19350117-19350833 | 1.00 | 2.26 × 10−2 | 9.96 × 10−1 | Intron | 5261 | ENSSSCG00000009403 | ITM2B | integral membrane protein 2B (Source:NCBI gene (formerly Entrezgene);Acc:595120) | 12 |
| chr12:30052250-30052448 | 1.02 | 4.87 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −109,077 | ENSSSCG00000017599 | KIF2B | kinesin family member 2B (Source:VGNC Symbol;Acc:VGNC:89468) | 3 |
| chr12:53660655-53660898 | −1.18 | 3.90 × 10−2 | 9.96 × 10−1 | Exon | −50,792 | ENSSSCG00000039032 | U6 | U6 spliceosomal RNA (Source:RFAM;Acc:RF00026) | 16 |
| chr12:59826222-59826441 | 1.56 | 2.74 × 10−3 | 6.80 × 10−1 | Intron | 19,267 | ENSSSCG00000018045 | ULK2 | unc-51 like autophagy activating kinase 2 (Source:VGNC Symbol;Acc:VGNC:94695) | 6 |
| chr13:7508-7838 | 1.18 | 3.37 × 10−3 | 6.80 × 10−1 | Distal Intergenic | 281,632 | ENSSSCG00000046931 | 9 | ||
| chr13:34107-34423 | 0.89 | 2.52 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 255,047 | 5 | |||
| chr13:37450-37723 | 1.03 | 2.98 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 251,747 | 5 | |||
| chr13:42463-42749 | 1.40 | 4.72 × 10−3 | 8.14 × 10−1 | Distal Intergenic | 246,721 | 7 | |||
| chr13:83112-83393 | 1.21 | 1.35 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 206077 | 5 | |||
| chr13:96003-97046 | 1.06 | 3.01 × 10−3 | 6.80 × 10−1 | Distal Intergenic | 192,424 | 18 | |||
| chr13:104471-105251 | 0.89 | 2.12 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 184,219 | 12 | |||
| chr13:109921-111269 | 0.79 | 3.21 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 178,201 | 27 | |||
| chr13:120981-122627 | 0.92 | 2.74 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 166,843 | 34 | |||
| chr13:133660-134567 | 1.30 | 2.51 × 10−3 | 6.80 × 10−1 | Distal Intergenic | 154,903 | 22 | |||
| chr13:138579-139179 | 1.02 | 2.88 × 10−2 | 9.96 × 10−1 | Distal Intergenic | 150,291 | 10 | |||
| chr13:80744108-80744758 | −1.08 | 3.46 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −44,636 | ENSSSCG00000011666 | CLSTN2 | calsyntenin 2 (Source:VGNC Symbol;Acc:VGNC:86785) | 6 |
| chr15:34797-35849 | −1.02 | 3.24 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −4170 | ENSSSCG00000047217 | 23 | ||
| chr15:134010175-134010376 | 1.18 | 4.26 × 10−2 | 9.96 × 10−1 | Intron | −4041 | ENSSSCG00000049095 | 5 | ||
| chr16:8511-12498 | 1.10 | 1.66 × 10−3 | 6.80 × 10−1 | Distal Intergenic | −30,855 | ENSSSCG00000022306 | ROPN1L | rhophilin associated tail protein 1 like (Source:VGNC Symbol;Acc:VGNC:92406) | 98 |
| chr16:13425-15353 | 0.77 | 1.10 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −28,000 | 45 | |||
| chr16:16135-17774 | 0.70 | 2.72 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −25,579 | 41 | |||
| chr16:19241-21132 | 0.80 | 8.75 × 10−3 | 9.96 × 10−1 | Distal Intergenic | −22,221 | 44 | |||
| chr16:21825-23929 | 0.77 | 1.18 × 10−2 | 9.96 × 10−1 | Distal Intergenic | −19,424 | ENSSSCG00000022306 | ROPN1L | rhophilin associated tail protein 1 like (Source:VGNC Symbol;Acc:VGNC:92406) | 50 |
| chr16:53839747-53839973 | 2.25 | 6.94 × 10−4 | 6.80 × 10−1 | Promoter | −638 | ENSSSCG00000017009 | FOXI1 | forkhead box I1 (Source:VGNC Symbol;Acc:VGNC:88208) | 14 |
| chr17:36220445-36220684 | 1.04 | 4.29 × 10−2 | 9.96 × 10−1 | Intron | −19,300 | ENSSSCG00000007249 | NOL4L | COMM domain containing 7 (Source:NCBI gene (formerly Entrezgene);Acc:100514995) | 7 |
| chr17:36220445-36220684 | 1.04 | 4.29 × 10−2 | 9.96 × 10−1 | Intron | −19,300 | 7 | |||
| chr18:1373929-1374129 | 1.09 | 3.31 × 10−2 | 9.96 × 10−1 | Intron | 12,247 | ENSSSCG00000037841 | ssc-mir-153 | ssc-mir-153 (Source:miRBase;Acc:MI0002454) | 7 |