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Schematic diagram of the angiogenesis pathway. FGF, ANG, VEGF, and IGF activate the PI3K/AKT pathway, promoting angiogenesis in the mouse diabetic wound model. FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor; ANG, angiopoietin; IGF, insulin-like growth factor; PI3K, phosphoinositide 3-kinase; AKT, protein kinase B; Spred-1, sprouty-related EVH1 domain-containing 1; ERK, extracellular signal-regulated kinase.
