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. 2021 Mar 5;13(5):1111. doi: 10.3390/cancers13051111

Figure 5.

Figure 5

Blockade of FAK activation inhibits migration and proliferation in LN229 and U251MG cells. (A–D) FAK inhibitor PF562271 (PF56) or PF573228 (PF57), reduced the levels of the active form of FAK (pY397-FAK) in a dose-dependent manner. FAK activation was inhibited over 90% at 10 μM in both cell lines. (E,F) FAK inhibitors PF56 and PF57 reduced cell migration in a wound scratch heal assays (at 10 μM of PF56 and PF57, 24 h). (G,H) Cell growth in the presence of 10 μM PF56 or PF57 as measured by direct cell counts. (I,J) Cell proliferation measured by BrdU proliferation assays in the presence of 10 μM PF56 or PF57. All experiments were repeated at least three times. Data are presented as mean ± SE. ** p < 0.01.