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. 2021 Mar 3;22(5):2529. doi: 10.3390/ijms22052529

Figure 2.

Figure 2

Direct and indirect effects of different Non-coding RNAs on the expression of ABCA1, which has a large 3′UTR region and is one of the most important transporters in cholesterol efflux [144,145]. In direct mechanism: non-coding RNAs able to bind to 3′UTR of ABCA1 mRNA transcript which ABCA1 expression regulate, in indirect mechanism: non-coding RNAs were not able to bind to 3′UTR of ABCA1 mRNA transcript although these noncoding RNAs that bind to 3′UTR of other mRNA transcript in turn regulate ABCA1 expression. It has also been shown that reducing inflammation increases the expression of this transporter and has a negative role in the formation of foam cells by increasing cholesterol efflux [148,149].