Table 2.
DNA methylation levels of miRNA loci in endometrial tissues.
| Reference | Date | Type of Review Article | Tumor Suppressor or OncomiR | miRNA | DNA Methylation Level | Methylation Target | Case Sample | Case Control | Detection Technique | |
|---|---|---|---|---|---|---|---|---|---|---|
| Yang et al. [14] | 2020 | Original article | OncomiR | miR-191 | hypomethylation | APC via TET1 | Endometrial Cell lines | Hydroxymethylated DNA Immunoprecipitation quantitative PCR | ||
| Ni J et al. [22] | 2020 | Original article | tumor supressor | miR-638 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 68) | Normal endometrial tissue (n = 68) | bisulfite sequencing/PCR | |
| Zhang et al. [23] | 2018 | Original article | Tumor supressor | miR-137 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 67) | Normal endometrial tissue (n = 10) | COBRA assay | |
| Yanokura et al. [24] | 2017 | Original article | Tumor supressor | miR-663 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 25) | Adjacent healthy tissue (n = 25) | bisulfite sequencing/PCR | |
| Devor et al. [25] | 2015 | Original article | OncomiR | miR-182 | hypomethylation | miRNA loci | Endometrial cancer tissue (n = 34); 18 endometrioid, 16 serous | Normal endometrial tissue (n = 6) | bisulfite sequencing/PCR | |
| Moreno-Moya et al. [139] | 2014 | Original article | OncomiR | miR-30d | hypermethylation | H19 | Endometrial epithelial cell (n = 4) | anti-5-methylcytosine monoclonal antibody | ||
| Li et al. [135] | 2013 | Original article | OncomiR | miR-200b | hypomethylation | miRNA loci | lynch endometrial cancer tissue (n = 19), other endometrial cancer tissue (n = 64) | Normal endometrial tissue (n = 22) | bisulfite sequencing/PCR | |
| Li et al. [135] | 2013 | Original article | OncomiR | miR-130a/b | hypomethylation | miRNA loci | lynch endometrial cancer tissue (n = 19), other endometrial cancer tissue (n = 64) | Normal endometrial tissue (n = 22) | bisulfite sequencing/PCR | |
| Li et al. [135] | 2013 | Original article | OncomiR | miR-625 | hypomethylation | miRNA loci | lynch endometrial cancer tissue (n = 19), other endometrial cancer tissue (n = 64) | Normal endometrial tissue (n = 22) | bisulfite sequencing/PCR | |
| Li et al. [135] | 2013 | Original article | OncomiR | miR-222 | hypomethylation | miRNA loci | lynch endometrial cancer tissue (n = 19), other endometrial cancer tissue (n = 64) | Normal endometrial tissue (n = 22) | bisulfite sequencing/PCR | |
| Hiroki et al. [136] | 2012 | Original article | Tumor supressor | miR-34b | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 41) | Normal endometrial tissue (n = 7) | bisulfite sequencing/PCR | |
| Pavicic et al. [137] | 2011 | original article | Tumor supressor | miR-124a-1 | miRNA loci | Endometrial cancer tissue (n = 41) | Normal endometrial tissue (n = 41) | bisulfite sequencing/PCR | ||
| Pavicic et al. [137] | 2011 | original article | Tumor supressor | miR-124a-2 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 41) | Normal endometrial tissue (n = 41) | bisulfite sequencing/PCR | |
| Pavicic et al. [137] | 2011 | original article | Tumor supressor | miR-124a-3 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 41) | Normal endometrial tissue (n = 41) | bisulfite sequencing/PCR | |
| Tsuruta et al. [21] | 2011 | original article | Tumor supressor | miR-152 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 70); 38 stage I, 8 stage II, 21 stage III, 3 stage IV | bisulfite sequencing/PCR | ||
| Pavicic et al. [137] | 2011 | Original article | OncomiR | miR-208a | hypomethylation | miRNA loci | Endometrial cancer tissue (n = 41) | Normal endometrial tissue (n = 41) | bisulfite sequencing/PCR | |
| Huang et al. [138] | 2009 | original article | Tumor supressor | miR-129-2 | hypermethylation | miRNA loci | Endometrial cancer tissue (n = 117) | Normal endometrial tissue (n = 7) | bisulfite sequencing/PCR | |
COBRA: The Combined Bisulfite Restriction Analysis; PCR: polymerase chain reaction.