5-FU |
5-fluorouracile |
aSMA |
Alpha-smooth-muscle actin |
BMDCs |
Bone marrow-derived dendritic cells |
BRAF |
Type B rapidly accelerated fibrosarcoma gene |
CAFs |
Cancer-associated fibroblasts |
CAM |
Cell-adhesion molecules |
CAR |
Chimeric antigen receptor |
CCL20 |
C-C Motif Chemokine Ligand 20 |
CCR6 |
C-C Motif Chemokine Receptor 6 () |
CD |
Cluster of Differentation |
CEA |
Carcinoembryonic antigen |
CMS |
Consensus molecular subtypes |
CRC |
Colorectal cancer |
CRISPR/Cas9 |
Clustered regularly interspaced short palindromic repeats/Cas9 |
CTLA-4 |
Cytotoxic T-Lymphocyte Antigen 4 |
CXCL5 |
C-X-C motif chemokine 5 |
CXCR4 |
C-X-C chemokine Receptor type 4 |
DCs |
Dendritic cells |
dMMR |
Deficient mismatch repair |
ECM |
Extracellular matrix |
EGF |
Epidermal Growth Factor |
FACS |
Fluorescence-activated cell sorting |
FAP |
Fibroblast-activated protein |
FDA |
Food and Drug Administration |
FGFR1 |
Fibroblast growth factor receptor 1 |
FOLFIRI |
Folinic acid, 5-FU and irinotecan treatment |
FSP1 |
Fibroblast-specific protein-1 |
HER2 |
Human EGF receptor 2 gene |
HGF |
Hepatocyte Growth Factor |
HIF-1 |
Hypoxia-inducible Factor 1 () |
ICAM |
Intercellular cell-adhesion molecules |
IGF |
Insulin-like growth factor ()) |
ILs |
Interleukins |
iNOS |
Induced nitric oxide synthase |
KRAS |
Kirsten rat sarcoma viral gene |
MARCO |
Macrophage receptor with collagenous structure |
mCRC |
Metastasic colorectal cancer |
MDSCs |
Myeloid-derived supressor cells |
MHC |
Major histocompatibility complex |
miRNAs |
MicroRNAs |
MMP |
Matrix metalloproteinases |
MMR |
Mismatch repair |
mRNA |
Messenger RNA |
MSI-H |
Microsatellite instability-high |
NGS |
Next generation sequencing |
NKs |
Natural killer cells |
NOTCH1 |
Neurogenic locus Notch Homolog protein 1 |
NRAS |
Neuroblastoma rat sarcoma viral gene |
NTRK |
Neurotrophic receptor tyrosine kinase gene |
PD-1 |
Programmed Death-ligand 1 |
PDGF |
Platelet-derived growth factor |
PDGFR |
Platelet-derived growth factor receptor |
PIK3CA |
Phosphatidylinositol 3-kinase catalytic subunit alpha gene |
PlGF |
Placental growth factor |
pMMR-MSI-L |
Mismatch repair-proficient-microsatellite instability-low |
PTEN |
Phosphatase and tensin homologue |
RAS |
Rat sarcoma oncogene |
ROS |
Reactive Oxygen Species |
siRNAs |
Small interfering RNA |
TAM |
Tumor-associated macrophage |
TGF-β |
Transforming Growth Factor β |
TIMP-1 |
Tissular inhibitor of metalloproteinases 1 |
TME |
Tumor microenvironment |
TNFα |
Tumor Necrosis Factor α |
TNM |
Tumor, Node, Metastases |
TRAIL |
TNF-Related Apoptosis Inducing Ligand |
Tsg101 |
Tumor susceptibility gene 101 |
VCAM |
Vascular cell-adhesion molecules |
VEGF |
Vascular Endothelial Growth Factor |