Figure 2.

The location of SNPs significantly associated with reproductive traits and diseases from GWAS studies in the region immediately upstream of the FSHB locus on chromosome 11. The scale at the bottom of the figure is given in kilobases (kb) based on coordinates for human chromosome 11 build hg38. Lead SNPs identified in individual studies are shown below the dotted line and the individual traits and diseases associated with those lead SNPs are listed in the boxes above the line (see Table 3). The four SNPs are all highly correlated and haplotype analysis showing the association of alleles for individual SNPs identified four common allelic combinations or haplotypes with the expected frequencies of each haplotype shown in the circles to the right of each combination.