Table 3.

Genetic association for common traits and diseases immediately upstream of the follicle stimulating hormone subunit beta (FSHB) on chromosome 11p14.1.

Trait	SNP	Position *	Pval	Effect Alleles &	Study
Menstrual cycle length	rs11031006	30,204,981	1.1 × 10−38	A > G	[20]
Age at menarche	rs11031006	30,204,981	8.49 × 10−14	A > G	[23]
Age at menopause	rs11031006	30,204,981	8.5 × 10−14	A > G	[31]
Dizygotic twinning	rs11031006	30,204,981	1.25 × 10−10	G > A	[44]
FSH concentrations	rs11031005 rs11031006	30,204,809 30,204,981	1.74 × 10−8 2.3 × 10−10	T > C G > A	[37] [44]
LH concentrations	rs11031002	30,193,714	3.94 × 10−9	T > A	[37]
Endometriosis	rs74485684	30,220,740	2.00 × 10−8	T > C	[27]
Polycystic ovarian syndrome	rs11031005	30,204,809	8.66 × 10−13	C > T	[45]
Excessive, frequent and irregular menstruation	rs11031006	30,204,981	1.1 × 10−38	A > G	[20]
Uterine fibroids	rs11031006	30,204,981	5.7 × 10−15	A > G	[54]
Bilateral oophorectomy	rs11031006	30,204,981	1.1 × 10−38	A > G	[20]

The LD between each listed SNP has an r² > 0.82, except for rs11031002 and rs74485684, which have an r² of 0.69 (European population); * Position on chromosome 11 (GRCh38.p12); & Direction of effect (allele increasing trait value or disease risk > alternative allele).