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. 2021 Mar 3;22(5):2535. doi: 10.3390/ijms22052535

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genetic variants and DNA methylation at the VTRNA2-1 region. Panel (a) shows the 9 variants identified via sequencing in the 179 participants of the multiple-case breast cancer family studies (ABCFR/kConFab). From left to right: rs62365993, rs7706795, rs2346018, rs2346019, rs34577747, rs1366231064, rs9327740, rs4976364, and rs74555710. Numbers within lollipops indicate the number of minor alleles observed in the sample. Panel (b)–(d) are from a random sample of 100 participants in the population-based study (MCCS), with coordinates: (b) 13401437–1354244 (26 CpGs), (c) 135415129–135416613 (19 CpGs), and (d) 135416381–135416412 (the 5 most heritable methylation marks).