Table 5.
Associations with breast cancer risk after adjustment for rs2346018 carrier probabilities a.
| CpG | Chromosome | Position | ∆l a | Not Adjusted for SNPs b | Adjusted for rs2346018 | ||
|---|---|---|---|---|---|---|---|
| Biased HR (95% CI) c | p-Value | Biased HR (95% CI) c | p-Value | ||||
| cg06536614 | 5 | 135416381 | 143.6 | 3.1 (2.1–4.6) | 7 × 10−9 | 3.0 (2.0–4.3) | 3 × 10−8 |
| cg00124993 | 5 | 135416412 | 108.0 | 3.2 (2.2–4.7) | 2 × 10−8 | 3.0 (2.0–4.4) | 9 × 10−8 |
| cg26328633 | 5 | 135416394 | 107.5 | 3.2 (2.2–4.8) | 2 × 10−8 | 3.0 (2.0–4.5) | 4 × 10−8 |
| cg25340688 | 5 | 135416398 | 105.9 | 3.2 (2.1–4.7) | 3 × 10−8 | 2.9 (2.0–4.3) | 1 × 10−7 |
| cg26896946 | 5 | 135416405 | 92.1 | 3.6 (2.4–5.4) | 2 × 10−9 | 3.3 (2.2–5.0) | 8 × 10−9 |
a ∆l: heritability metric: details of the methods used to calculate the heritability metric, carrier probabilities and Cox models for association with breast cancer risk are provided in [1]. b These are published and unpublished results from our study Joo et al., 2018 [1] and are presented here for comparison with the results adjusted for rs2346018. c While p values are unbiased, hazard ratios are biased by the ascertainment of families for this study [1], and the HR estimates are only included here to show that they are virtually unchanged by adjustment for rs2346018.