Figure 4.

Dietary emulsifier consumption alters the intestinal inflammatory environment in WT and APC^min female mice. Seven-week-old WT and APC^min female mice were exposed to drinking water containing CMC or P80 (1.0%) for 15 weeks. (A–C) Fecal lipocalin-2 (Lcn2) concentration and (D–F) bioactive levels of fecal lipopolysaccharide (LPS) and flagellin (FliC) (G–I) were assessed at day 0 (A,D,G), day 28 (B,E,H), and day 56 (C,F,I). Data are the means +/− S.E.M. (n = 5 for the WT–CTRL group, 3 for the APC^min–CTRL group, 7 for the WT–CMC group, 5 for the APC^min–CMC group, 6 for the WT–P80 group and 3 for the APC^min–P80 group). Significance was determined using one-way group ANOVA with a Bonferroni test (* indicates statistical significance).