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. 2021 Mar 12;218(4):e20202038. doi: 10.1084/jem.20202038

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© 2021 Kim and Cantor

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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graphic file with name JEM_20202038_Fig2.jpg — Studies on an agglutinogen (Rh) in human blood reacting with anti-Rhesus sera and with human isoantibodies. (A) Results from the original experiment that detected Rh factor in human blood using sera from rabbits immunized against Rhesus blood cells. Landsteiner and Wiener revealed a factor of human blood—Rh—that was independent of previously identified blood types M and N (from Landsteiner and Wiener, 1940, with permission of SAGE Publications, Ltd.). (B) Agglutination of fresh blood samples by guinea pig sera obtained following immunization with Rhesus blood cells (Landsteiner and Wiener, 1941). (C) Results of Landsteiner’s original 1941 Rh phenotype experiment using guinea pig immune sera and post-transfusion human serum. This table shows that the Rh factor is inherited as a simple Mendelian dominant trait (Landsteiner and Wiener, 1941).