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Schematic illustration of smart nanofiber mesh loaded with MNPs, DOX and 17AAG for combination therapy to treat breast cancer. The nanofiber generates hyperthermia effects from MNPs upon exposure to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced DOX chemotherapeutic efficiency. The efficiency of hyperthermia is further enhanced by releasing the 17AAG from the nanofiber mesh, which causes the inhibition of HSPs by hyperthermia.
