Table 1.
List of Zyxin family proteins containing LIM domain, their functions and biochemical properties.
| Protein (UNIPROT ID) | Cellular Role * | Cellular Localization |
Isoelectric Point 1 | Amino Acids/ Molecular Weight (kDa) 1 |
||
|---|---|---|---|---|---|---|
| Full Protein |
LIM DoMain | Full Protein | LIM Domain | |||
| Zyxin (Q15942) | Adhesion plague protein, signal transducer | Cytoskeleton, cytosol and nucleus | 6.22 | 7.16 | 572/61.27 | 189/21.10 |
| LimD1 (Q9UGP4) | Cell fate determination and a tumour suppressor | Predominantly in nucleus, P- body | 6.20 | 5.90 | 676/72.19 | 195/21.87 |
| Ajuba (Q96IF1) | Cell fate determination and repression of gene transcription | Cell membrane, cytoskeleton, centrosome, nucleus, P- body | 6.86 | 5.81 | 538/56.93 | 195/21.87 |
| LPP (Q93052) |
Maintains cell shape, motility, and activation of gene transcription | Cell membrane and nucleus | 7.18 | 6.78 | 612/65.74 | 190/21.15 |
| WTIP (A6NIX2) | Cell fate determination, repression of gene transcription, and miRNA-mediated gene silencing | Nucleus, P- body | 8.53 | 7.50 | 430/45.12 | 195/21.80 |
| FBLIM1 (Q8WUP2) | Cell-ECM adhesion proteins and filamin-containing actin filaments | Focal adhesion sites | 5.71 | 7.79 | 373/40.66 | 190/21.70 |
| TRIP6 (Q15654) | Relays signals from the cell surface to the nucleus | Focal adhesion sites, cytoplasm, nucleus | 7.19 | 6.06 | 476/50.28 | 188/20.49 |
* = Information retrieved from UniprotKB; 1 = Calculated using ProtParam.