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. 2021 Mar 5;13(5):1113. doi: 10.3390/cancers13051113

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The epigenetic landscape of the subtypes of meningioma. (A) Heatmap showing the most variable CpG loci across all subtypes of meningioma. Majority of CpG loci in the subtype 3 meningioma is hypermethylated. (B) Density plots showing the methylation levels of subtype specific CpG loci signatures across all subtypes. (C) long non-coding RNA (left) and miRNA (right) expression subdivide the subtypes of meningiomas. The differentially expressed long non-coding RNAs or microRNAs were utilized for heatmap clustering.