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Random forest identifies Alkaline Phosphatase (ALPL) as the feature genes in subtypes 3. (A) Top 20 important genes (variables) are ranked by Random Forest model. (B) ALPL in subtype 3 is significantly lower than that in the other subtypes of meningioma (One-way ANOVA: p < 2 × 10−16; post hoc, Tukey’s HSD test; * p < 0.05; *** p < 0.001). (C) The receiver operation curve shows the discrimination of subtype 3 over other subtypes of meningioma by ALPL expression.
