Table 1.

First line UDCA treatment response at 12 months.

Response Criteria at 12 Months of Standard UDCA Therapy	Total
Paris-I ALP < 3 × ULN + AST < 2 × ULN + bilirubin normalization	91.0% (253/278)
Paris-II ALP < 1.5 × ULN + AST < 1.5 × ULN + bilirubin normalization	71.3% (201/282)
Barcelona ALP ≤ 1 × ULN or reduction of ALP > 40%	61.3% (273/439)
ALP ≤ 1.67 × ULN	83.0% (365/440)
Bilirubin ≤ 1 × ULN	95.5% (383/401)
AP ≤ 1.67 × ULN + bilirubin normalization	80.8% (325/402)

UDCA: ursodeoxycholic acid; ALP: alkaline phosphatase; ULN: upper limit of normal; AST: aspartataminotransferase.