Table 1.
Values of IC50 (μM) determined for sphaerodactylomelol (0.1–100 μM) and standard drugs (0.1–500 μM) on tumorigenic cell lines and fibroblasts following 24 h treatment. The values represent the mean plus standard deviation. At least three independent experiments in triplicate were carried out.
| A549 | CACO-2 | HCT-15 | MCF-7 | NCI-H226 | PC-3 | SH-SY5Y | SK-MEL-28 | 3T3 | |
|---|---|---|---|---|---|---|---|---|---|
| Sphaerodactylomelol | 71.99 ± 15.65 | 89.41 ± 31.67 | 46.25 ± 10.05 | 47.19 ± 23.97 | 39.54 ± 9.22 | 58.21 ± 13.98 | 33.04 ± 8.76 | 40.51 ± 11.30 | 29.14 ± 3.64 |
| Cisplatin | 271.1 ± 111.10 | - | - | - | 172.9 ± 84.42 | 267.2 ± 67.14 | 13.92 ± 6.70 | 51.52 ± 6.87 | 137.0 ± 3.64 |
| Tamoxifen | - | - | - | 27.19 ± 21.53 | - | - | - | - | 15.34 ± 1.55 |
| 5-Fluororacil | - | 382.7 ± 32.95 | 155.5 ± 44.04 | - | - | - | - | - | 344.7 ± 19.69 |