Figure 2.

Metabolically fit chimeric antigen receptor (CAR) cells need to be generated for effective CAR immunotherapy. (A) When CAR immune cells reach their target, due to the paucity of nutrients, these cells can become exhausted. This prevents the CAR immune cells from functioning and allows for tumor growth. (B) Metabolically fit CAR immune cells can be generated by modifying the metabolic pathways that endow these immune cells to out-compete cancer cells for nutrients and thus remain active even in the TME for the eradication of cancer cells. (C) Metabolic pathways that are disrupted and can be modified to generate metabolically fit CAR-immune cells.