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. 2021 Mar 4;22(5):2576. doi: 10.3390/ijms22052576

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of EMPA on blood pressure and heart rate in PCOS. (A–C) Effect of EMPA on (A) systolic BP (SBP), (B) diastolic BP (DBP), and (C) mean arterial pressure (MAP) during last 3 weeks of DHT, with 4 days of baseline measurements. (D) Effect of EMPA on the light (L) and dark (D) phases of the circadian rhythm of MAP during the last 3 weeks of DHT, with 4 days of baseline. Data are expressed as mean ± SEM. Data was analyzed by two-way repeated measures ANOVA followed by Tukey post-hoc tests, with separate analyses for both baseline and for during EMPA treatment. No significant interactions were observed by two-way repeated measures ANOVA. * p < 0.05. n = 5–7 per group. SBP: Systolic blood pressure, DBP: Diastolic blood pressure, MAP: Mean arterial pressure.