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. 2021 Mar 4;22(5):2576. doi: 10.3390/ijms22052576

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of EMPA on mRNA expression of the intrarenal renin-angiotensin system in PCOS. Effect of EMPA on the renal cortical and medullar mRNA expression of (A) Ren (Renin), (B) Agt (Angiotensinogen), (C) AgtR1 (AT1R), and (D) ACE (angiotensin-converting enzyme), and (E) ACE2 (angiotensin-converting enzyme 2) after 3 weeks of EMPA treatment. Data are expressed as mean ± SEM. Data were analyzed by three-way ANOVA followed by Tukey post-hoc tests. Significant interaction was observed only for ACE2. * p < 0.05. n = 7–10 per group.