CTLA-4	cytotoxic T-lymphocyte-associated protein 4
CSCs	Cancer stem cells
ECOG	Eastern Cooperative Oncology Group
ICIs	Immune checkpoint inhibitors
IHC	Immunohistochemistry
IQR	Interquartile range
NR	Not reached
NSCLC	Non-small-cell lung cancer
ORR	Objective response rate
OS	Overall survival
PCR	Polimerase chain reaction
PFS	Progression free survival
PD-1	Programmed death-1
PD-L1	Programmed death-ligand 1
Shh	Sonic Hedgehog