| CTLA-4 | cytotoxic T-lymphocyte-associated protein 4 |
| CSCs | Cancer stem cells |
| ECOG | Eastern Cooperative Oncology Group |
| ICIs | Immune checkpoint inhibitors |
| IHC | Immunohistochemistry |
| IQR | Interquartile range |
| NR | Not reached |
| NSCLC | Non-small-cell lung cancer |
| ORR | Objective response rate |
| OS | Overall survival |
| PCR | Polimerase chain reaction |
| PFS | Progression free survival |
| PD-1 | Programmed death-1 |
| PD-L1 | Programmed death-ligand 1 |
| Shh | Sonic Hedgehog |
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