Figure 6.

Dinaciclib synergizes with cisplatin in EC cell lines. EC cell lines were treated either individually or in combination with dinaciclib at 5 and 10 nM concentrations and with concentrations of cisplatin reflective of their respective sensitivities (10 and 20 µM for Ishikawa and 20 and 40 µM for HEC-1A). Viability was measured and normalized to vehicle controls for (a) Ishikawa and (b) HEC-1A cells following 48 h of treatment. A combined treatment was considered synergistic where its viability was significantly lower than the viabilities of samples treated with the corresponding doses of each drug individually. Statistical significance was calculated by ANOVA followed by Dunnett’s test. * p value < 0.05, *** p value < 0.001.