. 2021 Mar 16;60(3):318–347. doi: 10.1007/s12016-021-08851-8

Table 2.

Protease activated receptor agonists

	Relations to C1-INH	Protease group	Receptor
	Relations to C1-INH	Protease group	PAR1	PAR2	PAR3	PAR4
Activating proteases	Inhibited by C1-INH	Serine proteases	Kallikrein-5, MASP-1, plasma kallikrein, plasmin, thrombin	Kallikrein-5, MASP-1, plasma kallikrein, plasmin	Plasmin, thrombin	MASP-1, plasmin, thrombin
	Not inhibited by C1-INH	Serine proteases	Cathepsin G, Factor VIIa, factor Xa, granzyme A, B, K, kallikrein 4, 6, 14, proteinase 3	Acrosin, cathepsin G, factor VIIa, factor Xa, granzyme A kallikrein 4, 6, 14, mast cell tryptase, matriptase, proteinase 3, testisin, tryptase	Factor Xa	Factor VIIa, factor Xa, cathepsin G, kallikrein 14
		Cysteine proteases	Calpain-1, gingipain	Calpain-1, cathepsin S, gingipain		Gingipain
		Metalloproteases	MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14
	Inactivates C1-INH	Serine proteases	Neutrophil elastase, trypsin	Elastase, neutrophil elastase, trypsin	Trypsin	Trypsin
Other agonists	C1-INH sensitive		C4a			C4a
Other agonists	Not inhibited by C1-INH			Zonula-occludens toxin, zonulin