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Schematic signaling pathway of the effect of downregulation of BTK expression on TPA-induced MMP-9 expression in MCF-7 cells. Inhibition of BTK expression attenuates TPA-induced MMP-9 expression and metastasis by blocking NF-κB and AP-1 activation via the PLCγ2/PKC/MAPK and IKK signaling pathways. →, activated; ⊥ means inhibited.
