Table 2.
(a). Receiver operating characteristics for the number of BAP-1 negative cells in relation to metastasis of uveal melanoma. * Optimal cutoff for proportion of BAP-1 negative tumor cells in given area. S.E., standard error. C.I., confidence interval. (b). Receiver operating characteristics for the number of BAP-1 negative cells in relation to gene expression class 2. * Optimal cutoff for proportion of BAP-1 negative tumor cells in given area. S.E., standard error. C.I., confidence interval.
| Tumor Area | AUC | S.E. | p | Asymptotic 95% CI | Cutoff * | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|---|
| Lower Bound | Upper Bound | |||||||
| (a) | ||||||||
| Full section | 0.89 | 0.050 | <0.0001 | 0.80 | 0.99 | 68% | 88% | 79% |
| Hot spots | 0.86 | 0.065 | <0.0001 | 0.73 | 0.98 | 46% | 81% | 92% |
| Cold spots | 0.86 | 0.060 | <0.0001 | 0.73 | 0.96 | 93% | 75% | 75% |
| Scleral margins | 0.86 | 0.058 | <0.0001 | 0.74 | 0.97 | 89% | 81% | 75% |
| (b) | ||||||||
| Full section | 0.86 | 0.078 | 0.002 | 0.70 | 1.00 | 61% | 100% | 83% |
| Hot spots | 0.85 | 0.071 | 0.002 | 0.72 | 0.99 | 33% | 82% | 83% |
| Cold spots | 0.85 | 0.071 | 0.001 | 0.71 | 0.99 | 93% | 82% | 78% |
| Scleral margins | 0.86 | 0.069 | 0.002 | 0.73 | 0.99 | 91% | 82% | 73% |