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. 2021 Mar 7;22(5):2689. doi: 10.3390/ijms22052689

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ATP13A2 promotes secretion of αsyn multimers. (a) Visualization of αsyn protein levels in total cell lysates and nanovesicle extracts from ATP13A2 KD, control, ATP13A2 WT, and ATP13A2 DN cells using Tsg101 as a control for the nanovesicle fraction. (b) Quantification of αsyn relative to Tsg101 (n = 3). Statistical analysis was performed using a one-way ANOVA test with Bonferroni. The error bars represent the SEM. * p < 0.05, ns, not significant. (c) Visualization of αsyn multimers after cross-linking in nanovesicles from ATP13A2 KD, control, and ATP13A2 DN cells without and with SPM using Tsg101 as a control for the nanovesicle fraction. (d) Quantification of ratio of αsyn multimers to DSP-Tsg101. Statistical analysis was performed using a one-way ANOVA test with Bonferroni. The error bars represent the SEM. ** p < 0.01, * p < 0.05, ns, not significant.