Table 4.
O3 and O2–O3 treatment in knee OA: anti-inflammatory properties.
| Reference | Intervention | Patients | Duration | Results |
|---|---|---|---|---|
| Babaei-Ghazani et al. [148] | 15 μg/mL intraarticular O2–O3 (10 mL) versus 40 mg intraarticular triamcinolone (1 mL) |
O2–O3 (N = 31) Triamcinolone (N = 31) |
12 weeks | The authors found an important reduction in joint effusion on ultrasound in both treatment arms at 3 months post-injection. |
| Lopes de Jesus et al. [167] | 20 μg/mL intraarticular O3 (10 mL) versus Placebo (10 mL air) |
O3 (N = 61) Placebo (N = 35) |
8 weeks | There was a significant improvement in joint stiffness at 8 weeks in the treatment arm. |
| Raeissadat et al. [166] | 3 weekly injections of 30 μg/mL intraarticular O3 (10 mL) versus 3 weekly injections of 20 mg/2 mL HA |
O3 (N = 67) HA (N = 74) |
24 weeks | Both groups demonstrated a notable amelioration in joint stiffness yet without significant discrepancies between the two treatment arms. |