Figure 4.
Effects of corticotropin-releasing hormone (CRH) and caffeine on the catagen-inducing factor transforming growth factor (TGF)-β2 in organ-cultured hair follicles. (a) Hair follicles were stained with immunofluorescence-labelled antibodies for TGF-β2 immunoreactivity (green fluorescence), which was detected in the outer root sheath (ORS) and partly in the inner root sheath (IRS). DP, dermal papilla. Bars = 50 μm. (b) Evaluation of the fluorescence intensity was conducted using Image J 1·38d software within the indicated white dashed rectangular areas. The data are expressed as the pooled mean ± SEM. *P < 0·05, ***P < 0·001.