Table 2.
Hematologic Data.*
| Patient Number | Months since Infusion | Hb | Hct | MCV | MCHC | HbF‡ | F-Cells§ | HbF per F-Cell, Baseline, Most Recent¶ | ARC (Normal, 43–85) | LDH (Normal, 100–210) |
|---|---|---|---|---|---|---|---|---|---|---|
| g/dl | % | fl | g/dl | % | % | pg | × 10−9/liter | U per liter | ||
| 2 | 24 | 11.4 | 32.5 | 87.8 | 35.1 | 22.7 | 71.0 | 27.4,¶ 9.4 | 215 | 217 |
| 3† | 18 | 9.5 | 28.9 | 86.3 | 32.9 | 20.4 | 58.9 | 5.6, 9.0 | 355 | 369 |
| 4 | 21 | 11.1 | 31.2 | 84.8 | 35.6 | 31.9 | 81.9 | 7.1, 11.2 | 160 | 301 |
| 6 | 15 | 11.0 | 32.5 | 76.0 | 33.8 | 38.8∥ | 65.3 | 5.0, 18.6∥ | 244 | 180 |
| 7 | 12 | 11.0 | 31.4 | 81.1 | 35.0 | 29.0 | 70.6 | 5.6, 11.1 | 130 | 485 |
| 8 | 6 | 9.3 | 25.5 | 88.9 | 36.5 | 41.3 | 93.6 | 6.8, 13.8 | 170 | 359 |
Data represent the most recent values available before the July 2020 data snapshot. ARC denotes absolute reticulocyte count, Hb hemoglobin, HbF fetal hemoglobin, Hct hematocrit, LDH lactate dehydrogenase, MCHC mean corpuscular hemoglobin concentration, and MCV mean corpuscular volume.
As of October 2020, Patient 3 has continued transfusions. At the most recent pretransfusion time point, HbA was 46.3%, HbS 39.0%, and HbF 12.1%.
HbF values are presented as HbF/(HbF + HbS).
F cells are reported as a percentage of untransfused red cells.
The average HbF per F-cell was calculated with the following formula: (MCH × HbF) per% F-cells. The HbF per F-cell calculation at baseline in Patient 2 was influenced by a very low baseline percentage of F-cells of 0.3%.
The most recent HbF was at 12 months, and the most recent HbF per F-cell calculation was at 10 months.