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. Author manuscript; available in PMC: 2021 Jul 21.
Published in final edited form as: N Engl J Med. 2020 Dec 5;384(3):205–215. doi: 10.1056/NEJMoa2029392

Table 3.

Vector Copy Number of Peripheral Blood and Bone Marrow (Copies per Diploid Genome).

Source and Time Point Patient 2 Patient 3 Patient 4 Patient 6 Patient 7 Patient 8
Peripheral blood
1.5 mo
 Whole blood 0.89 2.11 0.82 1.66 1.49 1.23
 CD19+ 0.003 0.02 0.03 0.03 0.06 0.03
 GlyA+, CD71+* 0.47 2.39 1.31 1.02 1.38 1.07
3 mo
 Whole blood 0.53 1.62 0.65 1.51 1.14 0.64
 CD19+ 0.3 1.2 0.48 1.11 0.68 0.55
 GlyA+, CD71+ 0.33 2.79 1.03 1.86 0.88 0.90
6 mo
 Whole blood 0.42 1.49 0.61 1.19 1.04 0.69
 CD19+ 0.5 1.21 0.5 1.13 0.66 0.64
 GlyA+, CD71+ 0.2 2.85 0.96 1.35 0.76 0.68
Most recent time point
 Whole blood 0.30 1.61 0.63 1.11 1.03 0.69
 CD19+ 0.43 1.37 0.61 1.11 0.78 0.64
 GlyA+, CD71+ 0.23 1.99 0.77 1.95 1.39 0.68
Bone marrow
6 mo
 CD34+ 0.53 1.52 0.60 1.20 0.86 0.59
 CD15+ 0.65 1.59 0.79 1.65 1.25 0.77
 GlyA+, CD71+ 0.63 1.62 0.80 1.42 1.34 0.73
*

CD19+ describes B-lymphoid cells, and GlyA+, CD71+ describes erythroid precursors.

Data are the most recent values available with vector copy number lineage sorting before the October 2020 data snapshot (range, 6 to 24 months).

Month 6 was the most recent time point for Patient 8.