Table 4.

Clinical Events before and after Infusion.^*

Patient Number	Months since Infusion	No. of Transfusions (Annualized)		No. of Severe Sickle Cell Clinical Events†
		Prestudy	After Engraftment	Prestudy	After Gene Therapy (<5 mo)	After Gene Therapy (≥5 mo)
2	29	12.5	0	0	0	0
3	19	10.5	5.7	0	0	0
4	20	2	0	13	5	1‡
6	16	3	0	6	0	0
7	12	11	0	0	0	0
8	7	1	0	3	0	0

^*Prestudy events represent the 2 years preceding study enrollment. Events that occurred after gene therapy represent the time from engraftment to the most recent follow-up.

^†Events include vaso-occlusive crisis pain requiring an emergency department visit or admission for opioid treatment, admission for acute chest syndrome, and priapism events requiring an emergency department visit or admission for a procedural intervention.

^‡The most recent severe event was an emergency department visit that occurred 8 months after gene therapy.