TABLE 1.
Demographic, clinical, cardiovascular, and neuroimaging characteristics
| AIBL CN sample | ORCA CN subsample | |||||
|---|---|---|---|---|---|---|
| Aβ‐ ε4‐ (n = 273) | Aβ‐ ε4+ (n = 60) | Aβ‐ ε4‐(n = 35) | Aβ‐ ε4+ (n = 13) | |||
| Mean (SD) | Mean (SD) | p | Mean (SD) | Mean (SD) | p | |
| N, Female (%) | 154 (46.2) | 33 (55.0) | .842 | 18 (60.0) | 5 (41.7) | .281 |
| Age at first assessment, y | 69.37 (5.87) | 67.69 (5.51) | .044 | 74.40 (4.93) | 73.85 (5.24) | .735 |
| Years of education | 12.36 (2.96) | 12.48 (3.05) | .790 | 13.85 (2.87) | 12.15 (3.11) | .083 |
| HADS‐anxiety† | 4.42 (2.85) | 4.79 (3.58) | .472 | 3.65 (2.97) | 4.00 (3.70) | .735 |
| HADS‐depression† | 2.60 (2.25) | 3.11 (2.44) | .211 | 2.32 (2.23) | 3.08 (2.66) | .331 |
| MMSE† | 28.86 (1.20) | 28.94 (1.10) | .616 | 29.12 (1.04) | 29.15 (1.21) | .919 |
| CDR Sum of Boxes† | 0.03 (0.16) | 0.04 (0.14) | .736 | 0.04 (0.19) | 0.19 (0.43) | .108 |
| Body mass index | 26.87 (4.15) | 26.25 (3.61) | .305 | 26.45 (3.67) | 25.39 (3.17) | .433 |
| Abdominal circumference, cm | 92.98 (13.28) | 92.44 (13.19) | .790 | 89.66 (11.27) | 90.70 (7.62) | .795 |
| Diastolic blood pressure, mmHg | 79.15 (10.33) | 77.24 (8.73) | .192 | 81.48 (9.18) | 78.60 (7.72) | .394 |
| Systolic blood pressure, mmHg | 136.52 (15.34) | 139.19 (15.22) | .230 | 136.74 (15.99) | 136.80 (7.76) | .991 |
| Centiloid† | 1.71 (9.87) | 2.70 (9.69) | .481 | 0.92 (4.63) | ‐0.60 (10.13) | .478 |
| Hippocampal volume, cm3† | 2.95 (0.29) | 2.97 (0.25) | .686 | 2.94 (0.25) | 3.01 (0.28) | .426 |
| N years between first PET scan and baseline AIBL cognitive assessment | 3.28 (2.54) | 2.61 (2.39) | .064 | – | – | – |
| N years between most recent PET scan and ORCA assessment | – | – | – | 1.31 (1.22) | 0.94 (0.84) | .319 |
| N AIBL cognitive assessments | 6.14 (1.20) | 6.27 (1.12) | .464 | 5.21 (2.31) | 4.69 (2.18) | .492 |
Abbreviations: AIBL, Australian Imaging, Biomarkers and Lifestyle Study; CDR, Clinical Dementia Rating; CN, cognitively normal; HADS, Hospital Anxiety and Depression Scale; MMSE, Mini‐Mental State Examination; ORCA, Online Repeatable Cognitive Assessment; PET, positron emission tomography; SD, standard deviation.
† obtained from the PET scan for the AIBL CN sample and closest PET scan to ORCA‐LLT assessment for the ORCA subsample; bolded values are significant at P < .05.